The Academy has been undertaking many pioneering ventures. Some of such records include.
- Velagapudi Ramakrishna Siddhartha Engineering College is the First Private Engineering College in the state of AP, 1977.
- Siddhartha Medical College was the First private Medical College in the state (1980-81).(Handed over to Government of A.P on its request)
- It is also the First institution in the private sector in the entire state to start M.Tech programmes (1999).
- Kommareddy Venkata Sadasiva Rao Siddhartha College of Pharmaceutical Sciences (1994) is the First Private Pharmacy college in the state.
- Parvataneni Brahmayya Siddhartha College of Arts & Science PG centre is the First Private institution to start PG programmes in Arts and science (1986-1987) in Vijayawada.
- First time in Andhra Pradesh, a Pharma Innovation and Incubation Centre (10,000 Sq.ft) is bulit in KVSR Siddhartha College of Pharmaceutical Science at cost of over Rs.1 Crore